It’s always exciting to be able to talk about a new publication from our team of brilliant and hard-working scientists. So I’m thrilled to tell you that our R&D team, led by Mikaela Nichkova and NeuroScience CEO & founder Gottfried Kellermann, recently published a report titled “Evaluation of a novel ELISA for serotonin: urinary serotonin as a potential biomarker for depression“.
Here’s some key takeaways:
- Good correlation was observed between urinary serotonin levels measured by ELISA and liquid chromatography tandem mass spectrometry.
- There was a good correlation between “spot” urine collection (a urine sample collected two hours after waking) and pooled 24 hour urine.
- Serotonin levels detected in depressed patients were significantly lower (p < 0.001) than in nondepressed subjects.
- Urinary excretion of serotonin in depressed individuals significantly increased after treatment by selective serotonin re-uptake inhibitors (SSRI) (p < 0.01).
The article appears in the December 9 issue of Analytical and Bioanalytical Chemistry. Happy reading!